For one- or two-term courses in Biophysical Chemistry. Usually taught at the senior/graduate level. Prerequisite: Introductory Biochemistry, some physical chemistry helpful.

The Second Edition of Principles of Physical Biochemistry provides the most current look at the theory and techniques used in the study of the physical chemistry of biological and biochemical molecules  including discussion of mass spectrometry and single-molecule methods. Leading experts in biophysical chemistry these well-known authors offer unique insights and coverage not available elsewhere.

Features

• A true teaching text, this book includes exercises at the end of every chapter along with more expanded solutions to half of the exercises.

• Clear writing by experts in the field makes the subject matter understandable.

New To This Edition

 • NEW - Comprehensive coverage of physical techniques currently used by practicing biochemists, including new chapters dedicated to extended material on mass spectrometry and single-molecule methods.

• NEW — A new streamlined organization – Groups all hydrodynamic methods in Chapter 5 and combines Raman spectroscopy with the spectroscopy section.

• NEW — Relevant Problems and Applications, approximately 20% of which are new, help students develop critical-thinking skills that they can apply to real biochemical and biological situations facing professionals in the industry.

Table of Contents

Chapter 1.  Biological Macromolecules  
Chapter 2.  Thermodynamics and Biochemistry
Chapter 3.  Molecular Thermodynamics
Chapter 4.  Statistical Thermodynamics
Chapter 5.  Methods for the Separation and Characterization of Macromolecules
Chapter 6.  X-Ray Diffraction
Chapter 7.  Scattering From Solutions of Macromolecules
Chapter 8.  Quantum Mechanics and Spectroscopy
Chapter 9.  Absorption Spectroscopy
Chapter 10.  Linear and Circular Dichroism
Chapter 11.  Emission Spectroscopy
Chapter 12.  Nuclear Magnetic Resonance Spectroscopy
Chapter 13.  Macromolecules in Solution:  Thermodynamics and Equilibria
Chapter 14.  Chemical Equilibria Involving Macromolecules
Chapter 15.  Mass Spectrometry of Macromolecules
Chapter 16.  Single-Molecule Methods
Solutions to Odd-Numbered Problems

Index