Biochemistry, Third Edition merges a classical organization and presentation with contemporary insight, information, and technology, to make modern biochemistry interesting and accessible to today's students. Thoroughly updated to include the latest information, perspectives, and experimental techniques, the text is now supported by integrated media resources designed by the co-author Kevin Ahern. Together, the text and media resources provide students and instructors with a doorway to the vast world of biochemistry that is continuously evolving and which greatly exceeds what could be covered in a conventional textbook alone. As in previous editions, the authors introduce nucleic acid structure early (to clarify presentations of protein structure and function), emphasize the experimental roots of biochemistry (past and present), continually emphasize the energy relationships in biochemistry, and take a stepwise approach to complex metabolic pathways. The result is a thorough grounding in biology at the atomic/molecular level. The explosive growth of biochemistry, molecular biology, and biotechnology makes this approach particularly relevant for today's life science students.
I. THE REALM OF BIOCHEMISTRY.
1. The Scope of Biochemistry.
2. The Matrix of Life: Weak Interactions in an Aqueous Environment.
3. The Energetics of Life.
II. MOLECULAR ARCHITECTURE OF LIVING MATTER.
4. Nucleic Acids.
5. Introduction to Proteins: The Primary Level of Protein Structure.
6. The Three- Dimensional Structure of Proteins.
7. Protein Function and Evolution.
8. Proteins in Motion: Contractile Systems and Molecular Motors.
10. Lipids, Membranes, and Cellular Transport.
III. DYNAMICS OF LIFE: CATALYSIS AND CONTROL OF BIOCHEMICAL REACTIONS. 11. Enzymes: Biological Catalysts.
12. Introduction to Metabolism.
IV. DYNAMICS OF LIFE: ENERGY, BIOSYNTHESIS, AND UTILIZATION OF PRECURSORS.
13. Carbohydrate Metabolism I: Anaerobic Processes in Generating Metabolic Energy.
14. Oxidative Processes: Citric Acid Cycle and Pentose Phosphate Pathway.
15. Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism.
16. Carbohydrate Metabolism II: Biosynthesis.
18. Lipid Metabolism I: Fatty Acids, Triacylglycerols, and Lipoproteins.
19. Lipid Metabolism II: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids.
20. Metabolism of Nitrogenous Compounds: Principles of Biosynthesis, Utilization, and Turnover.
21. Metabolism of Nitrogenous Compounds: Amino Acids, Porphyrins, and Neurotransmitters.
22. Nucleotide Metabolism.
23. Metabolic Coordination, Metabolic Control, and Signal Transduction
24. Information Copying: Replication.
25. Information Restructuring: Restriction, Repair, Recombination, Rearrangement, and Amplification.
26. Information Readout: Transcription.
27. Information Decoding: Translation.
28. Eukaryotic Genes and Their Expression.
Answers to Problems.