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Histology: A Text and Atlas, 7/e
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ÆǸŰ¡°Ý  : 76,000¿ø
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ÃâÆǻ砠: Wolters Kluwer
ÀúÀÚ  : Ross, Pawlina
¹ßÇàÀÏ  : 2015.01
ÆäÀÌÁö ¼ö  : 992¸é
ISBN  : 9781469889313
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Now in its seventh edition, Histology: A Text and Atlas is ideal for medical, dental, health professions, and undergraduate biology and cell biology students. This best-selling combination text and atlas includes a detailed textbook, which emphasizes clinical and functional correlates of histology fully supplemented by vividly informative illustrations and photomicrographs. Separate, superbly illustrated atlas sections follow almost every chapter and feature large-size, full-color digital photomicrographs with accompanied descriptions that highlight structural and functional details of cells, tissues, and organs.Updated throughout to reflect the latest advances in the field, this ¡°two in one¡± text and atlas features an outstanding art program with all illustrations completely revised and redrawn as well as a reader-friendly format including red highlighted key terms, blue clinical text, and folders that cover clinical correlations and functional considerations.NEW! All illustrations are now completely revised and redrawn for a consistent art program.NEW! Histology 101 sections provide students with a reader-friendly review of essential information covered in the preceding chapters.NEW! Updated cellular and molecular biology coverage reflects the latest advances in the field.More than 100 atlas plates that incorporate 435 full-color, high-resolution photomicrographs.Reader-friendly highlights including red bold terms, blue clinical text, and folders featuring clinical and functional correlations increase student understanding and facilitates efficient study.Easy-to-understand tables aid students in learning and reviewing information (such as staining techniques) without having to rely on rote memorization.Features of cells, tissues, and organs and their functions and locations are presented in easy-to-locate, easy-to-review bulleted lists.Additional clinical correlation and functional consideration folders have been added providing information related to symptoms, photomicrographs of diseased tissues or organs, short histopathological descriptions, and molecular basis for clinical intervention.


1.METHODS | 1 Overview of Methods Used in Histology| 1 | 2 Histochemistry and Cytochemistry| 3 Microscopy| 13 Folder 1.1Clinical Correlation: Frozen Sections | 4 Folder 1.2Microspectrophotometry | 7Functional Considerations: Feulgen Folder 1.3Medicine | 9Clinical Correlation: Monoclonal Antibodies in Folder 1.4Proper Use of the Light Microscope | 11

 

 2.CELL CYTOPLASM | 22 Overview of the Cell and Cytoplasm| 22 Membranous Organelles| 25 Nonmembranous Organelles| 56 Inclusions| 71 Cytoplasmic Matrix| 73 Folder 2.1Diseases | 42Clinical Correlation: Lysosomal Storage Folder 2.2Microtubules and Filaments | 68Clinical Correlation: Abnormalities in Folder 2.3of Centrioles and Cancer | 72Clinical Correlation: Abnormal Duplication

 

3.THE CELL NUCLEUS | 75 Overview of the Nucleus| 75 Nuclear Components| 75 Cell Renewal| 84 Cell Cycle| 86 Cell Death| 93 Folder 3.1Clinical Correlation: Cytogenetic Testing | 80 Folder 3.2and Cancer Treatment | 81Clinical Correlation: Regulation of Cell Cycle

 

4.CLASSIFICATION |TISSUES: CONCEPT AND98 Overview of Tissues| 98 Epithelium| 99 Connective Tissue| 99 Muscle Tissue| 100 Nerve Tissue| 101 Histogenesis of Tissues| 102 Identifying Tissues| 102 Folder 4.1Clinical Correlation: Ovarian Teratomas | 103

 

5.EPITHELIAL TISSUE | 105 Overview of Epithelial Structure and Function| 105 Classification of Epithelium| 106 Cell Polarity| 107 The Apical Domain and its Modifications| 109 The Lateral Domain and its Specializations inCell-To-Cell Adhesion| 121 The Basal Domain and its Specializations inCell-To-Extracellular Matrix Adhesion| 134 Glands| 146 Epithelial Cell Renewal| 150 Folder 5.1Clinical Correlation: Epithelial Metaplasia | 109 Folder 5.2Dyskinesia | 120Clinical Correlation: Primary Ciliary Folder 5.3as a Target of Pathogenic Agents | 128Clinical Correlation: Junctional Complexes Folder 5.4Membrane and Basal LaminaTerminology | 138Functional Considerations: Basement Folder 5.5Serous Membranes | 150Functional Considerations: Mucus and Atlas PlatesPlate 1Epithelia | 152Simple Squamous and Cuboidal Plate 2Simple and Stratified Epithelia | 154 Plate 3Tissues | 156Stratified Epithelia and Epithelioid

 

6.CONNECTIVE TISSUE | 158 General Structure and Function ofConnective Tissue| 158 Embryonic Connective Tissue| 159 Connective Tissue Proper| 160 Connective Tissue Fibers| 161 Extracellular Matrix| 173 Connective Tissue Cells| 178 Folder 6.1Clinical Correlation: Collagenopathies | 170 Folder 6.2Molecular Changes in Photoaged Skin | 173Clinical Correlation: Sun Exposure and Folder 6.3Wound Repair | 183Clinical Correlation: Role of Myofibroblasts in Folder 6.4Phagocytotic System | 185Functional Considerations: The Mononuclear Folder 6.5and Basophils in Allergic Reactions | 188Clinical Correlation: The Role of Mast Cells Atlas PlatesPlate 4Tissue | 192Loose and Dense Irregular Connective Plate 5Ligaments | 194Dense Regular Connective Tissue, Tendons, and Plate 6Elastic Fibers and Elastic Lamellae | 196

 

7.CARTILAGE | 198 Overview of Cartilage| 198 Hyaline Cartilage| 199 Elastic Cartilage| 204 Fibrocartilage| 204 Chondrogenesis and Cartilage Growth| 206 Repair of Hyaline Cartilage| 207 Folder 7.1Clinical Correlation: Osteoarthritis | 199 Folder 7.2the Cartilage; Chondrosarcomas | 208Clinical Correlation: Malignant Tumors of Atlas PlatesPlate 7Hyaline Cartilage | 210 Plate 8Cartilage and the Developing Skeleton | 212 Plate 9Elastic Cartilage | 214 Plate 10Fibrocartilage | 216

 

8.BONE | 218 Overview of Bone| 218 Bones and Bone Tissue| 219 General Structure of Bones| 220 Cells of Bone Tissue| 223 Bone Formation| 232 Biologic Mineralization and Matrix Vesicles| 241 Physiologic Aspects of Bone| 242 Folder 8.1Clinical Correlation: Joint Diseases | 221 Folder 8.2Clinical Correlation: Osteoporosis | 233 Folder 8.3in Bone Formation | 234Clinical Correlation: Nutritional Factors Folder 8.4Regulation of Bone Growth | 242Functional Considerations: Hormonal Atlas PlatesPlate 11Bone, Ground Section | 244 Plate 12Bone and Bone Tissue | 246 Plate 13Endochondral Bone Formation I | 248 Plate 14Endochondral Bone Formation II | 250 Plate 15Intramembranous Bone Formation | 252

 

9.ADIPOSE TISSUE | 254 Overview of Adipose Tissue| 254 White Adipose Tissue| 254 Brown Adipose Tissue| 259 Folder 9.1Clinical Correlation: Obesity | 261 Folder 9.2Clinical Correlation: Adipose Tissue Tumors | 262 Folder 9.3Brown Adipose Tissue Interference | 264Clinical Correlation: PET Scanning and Atlas PlatesPlate 16Adipose Tissue | 266

 

10.BLOOD | 268 Overview of Blood| 268 Plasma| 269 Erythrocytes| 270 Leukocytes| 275 Thrombocytes| 286 Formation of Blood Cells (Hemopoiesis)| 289 Bone Marrow| 298 Folder 10.1Group Systems | 273Clinical Correlation: ABO and Rh Blood Folder 10.2with Diabetes | 274Clinical Correlation: Hemoglobin in Patients Folder 10.3Clinical Correlation: Hemoglobin Disorders | 276 Folder 10.4Neutrophils; Chronic Granulomatous Disease(CGD) | 281Clinical Correlation: Inherited Disorders of Folder 10.5and Jaundice | 281Clinical Correlation: Hemoglobin Breakdown Folder 10.6Marrow | 300Clinical Correlation: Cellularity of the Bone Atlas PlatesPlate 17Erythrocytes and Granulocytes | 302 Plate 18Agranulocytes and Red Marrow | 304 Plate 19Erythropoiesis | 306 Plate 20Granulopoiesis | 308

 

11.MUSCLE TISSUE | 310 Overview and Classification of Muscle| 310 Skeletal Muscle| 311 Cardiac Muscle| 327 Smooth Muscle| 331 Folder 11.1and Ischemia | 316Functional Considerations: Muscle Metabolism Folder 11.2Dystrophin and Dystrophin- AssociatedProteins | 319Clinical Correlation: Muscular Dystrophies— Folder 11.3Filament Model | 323Functional Considerations: The Sliding Folder 11.4Clinical Correlation: Myasthenia Gravis | 325 Folder 11.5the Three Muscle Types | 337Functional Considerations: Comparison of Atlas PlatesPlate 21Skeletal Muscle I | 340 Plate 22Skeletal Muscle II and Electron Microscopy | 342 Plate 23Myotendinal Junction | 344 Plate 24Cardiac Muscle | 346 Plate 25Cardiac Muscle, Purkinje Fibers | 348 Plate 26Smooth Muscle I | 350

 

12.NERVE TISSUE | 352 Overview of the Nervous System| 352 Composition of Nerve Tissue| 353 The Neuron| 353 Supporting Cells of the Nervous System;The Neuroglia| 363 Origin of Nerve Tissue Cells| 373 Organization of the Peripheral Nervous System| 375 Organization of the Autonomic Nervous System| 378 Organization of the Central Nervous System| 381 Response of Neurons to Injury| 386 Folder 12.1Clinical Correlation: Parkinson¡¯s Disease | 358 Folder 12.2Clinical Correlation: Demyelinating Diseases | 366 Folder 12.3in the CNS | 389Clinical Correlation: Gliosis: Scar formation Atlas PlatesPlate 27Sympathetic and Dorsal Root Ganglia | 390 Plate 28Peripheral Nerve | 392 Plate 29Cerebrum | 394 Plate 30Cerebellum | 396 Plate 31Spinal Cord | 398

 

13.CARDIOVASCULAR SYSTEM | 400 Overview of the Cardiovascular System| 400 Heart| 402 General Features of Arteries and Veins| 408 Arteries| 414 Capillaries| 421 Arteriovenous Shunts| 423 Veins| 424 Atypical Blood Vessels| 426 Lymphatic Vessels| 427 Folder 13.1Clinical Correlation: Atherosclerosis | 411 Folder 13.2Clinical Correlation: Hypertension | 416 Folder 13.3Clinical Correlation: Ischemic Heart Disease | 429 Atlas PlatesPlate 32Heart | 432 Plate 33Aorta | 434 Plate 34Muscular Arteries and Veins | 436 Plate 35Arterioles, Venules, and Lymphatic Vessels | 438

 

14.LYMPHATIC SYSTEM | 440 Overview of the Lymphatic System| 440 Cells of the Lymphatic System| 441 Lymphatic Tissues and Organs| 453 Folder 14.1Names T Lymphocyte and B Lymphocyte | 447Functional Considerations: Origin of the Folder 14.2Reactions | 447Clinical Correlation: Hypersensitivity Folder 14.3Virus (HIV) and Acquired ImmunodeficiencySyndrome (AIDS) | 455Clinical Correlation: Human Immunodeficiency Folder 14.4Lymphadenitis | 466Clinical Correlation: Reactive (Inflammatory) Atlas PlatesPlate 36Palatine Tonsil | 476 Plate 37Lymph Node I | 478 Plate 38Lymph Node II | 480 Plate 39Spleen I | 482 Plate 40Spleen II | 484 Plate 41Thymus | 486

 

15.INTEGUMENTARY SYSTEM | 488 Overview of the Integumentary System| 488 Layers of the Skin| 489 Cells of the Epidermis| 493 Structures of Skin| 501 Folder 15.1Origin | 492Clinical Correlation: Cancers of Epidermal Folder 15.2Functional Considerations: Skin Color | 499 Folder 15.3and Hair Characteristics | 504Functional Considerations: Hair Growth Folder 15.4Sebum | 505Functional Considerations: The Role of Folder 15.5Disease | 507Clinical Correlation: Sweating and Folder 15.6Clinical Correlation: Skin Repair | 512 Atlas PlatesPlate 42Skin I | 514 Plate 43Skin II | 516 Plate 44Apocrine and Eccrine Sweat Glands | 518 Plate 45Sweat and Sebaceous Glands | 520 Plate 46Integument and Sensory Organs | 522 Plate 47Hair Follicle and Nail | 524

 

16.ORAL CAVITY ANDASSOCIATED STRUCTURES |DIGESTIVE SYSTEM I:526 Overview of the Digestive System| 526 Oral Cavity| 527 Tongue| 529 Teeth and Supporting Tissues| 534 Salivary Glands| 545 Folder 16.1of Taste | 533Clinical Correlation: The Genetic Basis Folder 16.2Permanent (Secondary) and Deciduous(Primary) Dentition | 534Clinical Correlation: Classification of Folder 16.3Clinical Correlation: Dental Caries | 547 Folder 16.4Clinical Correlation: Salivary Gland Tumors | 555 Atlas PlatesPlate 48Lip, A Mucocutaneous Junction | 556 Plate 49Tongue I | 558 Plate 50Tongue II - Foliate Papillae and Taste Buds | 560 Plate 51Submandibular Gland | 562 Plate 52Parotid Gland | 564 Plate 53Sublingual Gland | 566

 

17.ESOPHAGUS ANDGASTROINTESTINAL TRACT |DIGESTIVE SYSTEM II:568 Overview of the Esophagus and GastrointestinalTract| 569 Esophagus| 572 Stomach| 574 Small Intestine| 586 Large Intestine| 597 Folder 17.1and Peptic Ulcer Disease | 578Clinical Correlation: Pernicious Anemia Folder 17.2Syndrome | 580Clinical Correlation: Zollinger-Ellison Folder 17.3Endocrine System | 581Functional Considerations: The Gastrointestinal Folder 17.4Absorptive Functions of Enterocytes | 587Functional Considerations: Digestive and Folder 17.5of the Alimentary Canal | 595Functional Considerations: Immune Functions Folder 17.6Vessel Distribution and Diseases of theLarge Intestine | 602Clinical Correlation: The Pattern of Lymph Atlas PlatesPlate 54Esophagus | 606 Plate 55Esophagus And Stomach, Cardiac Region | 608 Plate 56Stomach I | 610 Plate 57Stomach II | 612 Plate 58Gastroduodenal Junction | 614 Plate 59Duodenum | 616 Plate 60Jejunum | 618 Plate 61Ileum | 620 Plate 62Colon | 622 Plate 63Appendix | 624 Plate 64Anal Canal | 626

 

18.GALLBLADDER, AND PANCREAS |DIGESTIVE SYSTEM III: LIVER,628 Liver| 628 Gallbladder| 643 Pancreas| 647 Folder 18.1Clinical Correlation: Lipoproteins | 630 Folder 18.2Failure and Liver Necrosis | 635Clinical Correlation: Congestive Heart Folder 18.3Disease | 655Insulin Production and Alzheimer¡¯s Folder 18.4Synthesis, an Example ofPosttranslational Processing | 655Functional Considerations: Insulin Atlas PlatesPlate 65Liver I | 656 Plate 66Liver II | 658 Plate 67Gallbladder | 660 Plate 68Pancreas | 662

 

19.RESPIRATORY SYSTEM | 664 Overview of the Respiratory System| 664 Nasal Cavities| 665 Pharynx| 670 Larynx| 670 Trachea| 670 Bronchi| 676 Bronchioles| 677 Alveoli| 678 Blood Supply| 687 Lymphatic Vessels| 687 Nerves| 687 Folder 19.1in the Respiratory Tract | 672Clinical Correlations: Squamous Metaplasia Folder 19.2Clinical Correlations: Cystic Fibrosis | 685 Folder 19.3Pneumonia | 686Clinical Correlations: Emphysema and Atlas PlatesPlate 69Olfactory Mucosa | 688 Plate 70Larynx | 690 Plate 71Trachea | 692 Plate 72Bronchioles and End Respiratory Passages | 694 Plate 73and Alveolus | 696Terminal Bronchiole, Respiratory Bronchiole,

 

20.URINARY SYSTEM | 698 Overview of the Urinary System| 698 General Structure of the Kidney| 699 Kidney Tubule Function| 714 Interstitial Cells| 720 Histophysiology of the Kidney| 720 Blood Supply| 721 Lymphatic Vessels| 723 Nerve Supply| 723 Ureter, Urinary Bladder, and Urethra| 723 Folder 20.1Vitamin D | 699Functional Considerations: Kidney and Folder 20.2Membrane Antibody-Induced Glomerulonephritis;Goodpastue Syndrome | 712Clinical Correlation: Antiglomerular Basement Folder 20.3Urine—Urinalysis | 714Clinical Correlation: Examination of the Folder 20.4Renin–Angiotensin–Aldosterone System andHypertension | 714Clinical Correlation: Function of Aquaporin Water Channels | 717Folder 20.5 Functional Considerations: Structure and Folder 20.6Regulation of Collecting Duct Function | 721Functional Considerations: Hormonal Atlas PlatesPlate 74KIDNEY I | 728 Plate 75KIDNEY II | 730 Plate 76KIDNEY III | 732 Plate 77KIDNEY IV | 734 Plate 78URETER | 736 Plate 79URINARY BLADDER | 738

 

21.ENDOCRINE ORGANS | 740 Overview of the Endocrine System| 740 Pituitary Gland (Hypophysis)| 742 Hypothalamus| 751 Pineal Gland| 752 Thyroid Gland| 755 Parathyroid Glands| 760 Adrenal Glands| 762 Folder 21.1Pituitary Gland Secretion | 743Functional Considerations: Regulation of Folder 21.2Diseases | 750Clinical Correlation: Principles of Endocrine Folder 21.3with ADH Secretion | 753Clinical Correlation: Pathologies Associated Folder 21.4Clinical Correlation: Abnormal Thyroid Function | 758 Folder 21.5Pheochromocytoma | 766Clinical Correlation: Chromaffin Cells and Folder 21.6of Adrenal Hormones | 769Functional Considerations: Biosynthesis Atlas PlatesPlate 80Pituitary I | 772 Plate 81Pituitary II | 774 Plate 82Pineal Gland | 776 Plate 83Parathyroid and Thyroid Glands | 778 Plate 84Adrenal Gland I | 780 Plate 85Adrenal Gland II | 782

 

22.MALE REPRODUCTIVE SYSTEM | 784 Overview of the Male Reproductive System| 784 Testis| 784 Spermatogenesis| 792 Seminiferous Tubules| 798 Intratesticular Ducts| 802 Excurrent Duct System| 803 Accessory Sex Glands| 808 Prostate Gland| 808 Semen| 813 Penis| 813 Folder 22.1Regulation of Spermatogenesis | 788Functional Considerations: Hormonal Folder 22.2Spermatogenesis | 789Clinical Correlation: Factors Affecting Folder 22.3and the Immune Response | 803Clinical Correlation: Sperm-Specific Antigens Folder 22.4Hypertrophy and Cancer of the Prostate | 811Clinical Correlation: Benign Prostatic Folder 22.5and Erectile Dysfunction | 815Clinical Correlation: Mechanism of Erection Atlas PlatesPlate 86Testis I | 818 Plate 87Testis II | 820 Plate 88Efferent Ductules and Epididymis | 822 Plate 89Spermatic Cord and Ductus Deferens | 824 Plate 90Prostate Gland | 826 Plate 91Seminal Vesicle | 828

 

23.SYSTEM |FEMALE REPRODUCTIVE830 Overview of the Female Reproductive System| 830 Ovary| 831 Uterine Tubes| 845 Uterus| 848 Placenta| 854 Vagina| 860 External Genitalia| 861 Mammary Glands| 863 Folder 23.1Disease | 839Clinical Correlation: Polycystic Ovarian Folder 23.2Clinical Correlation: In Vitro Fertilization | 844 Folder 23.3Hormonal Regulation of the Ovarian Cycle | 846Functional Considerations: Summary of Folder 23.4Placenta at Birth | 860Clinical Correlation: Fate of the Mature Folder 23.5Clinical Correlation: Cytologic Pap Smears | 862 Folder 23.6Infections | 868Clinical Correlation: Cervix and HPV Folder 23.7Infertility | 870Functional Considerations: Lactation and Atlas PlatesPlate 92Ovary I | 872 Plate 93Ovary II | 874 Plate 94Corpus Luteum | 876 Plate 95Uterine Tube | 878 Plate 96Uterus I | 880 Plate 97Uterus II | 882 Plate 98Cervix | 884 Plate 99Placenta I | 886 Plate 100Placenta II | 888 Plate 101Vagina | 890 Plate 102Mammary Gland–Inactive Stage | 892 Plate 103Lactating Stages | 894Mammary Gland, Late Proliferative and

 

24.EYE | 896 Overview of the Eye| 896 General Structure of the Eye| 896 Microscopic Structure of the Eye| 899 Folder 24.1Clinical Correlation: Glaucoma | 905 Folder 24.2Clinical Correlation: Retinal Detachment | 908 Folder 24.3Degeneration (ARMD) | 909Clinical Correlation: Age-Related Macular Folder 24.4Clinical Correlation: Conjunctivitis | 917 Atlas PlatesPlate 104Eye I | 920 Plate 105Eye II: Retina | 922 Plate 106Eye III: Anterior Segment | 924 Plate 107Eye IV: Sclera, Cornea, and Lens | 926

 

25.EAR | 928 Overview of the Ear| 928 External Ear| 928 Middle Ear| 929 Internal Ear| 932 Folder 25.1Clinical Correlation: Otosclerosis | 933 Folder 25.2Dysfunction | 934Clinical Correlation: Hearing Loss—Vestibular Folder 25.3Clinical Correlation: Vertigo | 937 Atlas PlatesPlate 108Ear | 946 Plate 109Cochlear Canal and Organ of Corti | 948 Index | 950Tissue PreparationPreface | viiAcknowledgments | ix

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