Part One Genes, Chromosomes, and Heredity

1 Introduction to Genetics 1

2 Mitosis and Meiosis 17

3 Mendelian Genetics 39

4 Extensions of Mendelian Genetics 66

5 Chromosome Mapping in Eukaryotes 100

6 Genetic Analysis and Mapping in Bacteria and Bacteriophages 137

7 Sex Determination and Sex Chromosomes 165

8 Chromosome Mutations: Variation in Chromosome Number and Arrangement 187

9 Extranuclear Inheritance 214

Part Two DNA: Structure, Replication, and Variation

10 DNA Structure and Analysis 231

11 DNA Replication and Recombination 263

12 DNA Organization in Chromosomes 286

Part Three Expression and Regulation of Genetic Information

13 The Genetic Code and Transcription 306

14 Translation and Proteins 334

15 Gene Mutation, DNA Repair, and Transposition 361

16 Regulation of Gene Expression in Prokaryotes 392

17 Regulation of Gene Expression in Eukaryotes 411

18 Cell Cycle Regulation and Cancer 434

Part Four Genomic Analysis

19 Recombinant DNA Technology 457

20 Genomics and Proteomics 484

21 Dissection of Gene Function: Mutational Analysis in Model Organisms 516

22 Applications and Ethics of Biotechnology 549

Part Five Genetics of Organisms and Populations

23 Developmental Genetics of Model Organisms 575

24 Quantitative Genetics and Multifactorial Traits 599

25 Population Genetics 617

26 Evolutionary Genetics 640

27 Conservation Genetics 663

Appendix A Glossary A-1

Appendix B Answers to Selected Problems A-17